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Nephrology & Renal Medicine

Central Diabetes Insipidus

ICD-10 Code
E23.2

Profound polyuria and hypernatremia caused by a lack of ADH production/secretion from the posterior pituitary. Often secondary to head trauma, pituitary surgery, or tumors.

Clinical Presentation & Protocol

Patient Usually Complains Of

Patient presents with profound polyuria (urine output >3L/day) and polydipsia, specifically craving cold water. Onset is [acute/insidious], associated with [head trauma/pituitary surgery/neoplasm]. Denies glycosuria or symptoms of hyperglycemia. Current fluid intake is [X] L/day.

Clinical Examination Findings

General: Patient appears [well-hydrated/dehydrated] with dry mucous membranes and poor skin turgor. Vitals: Tachycardia noted, BP stable/orthostatic hypotension present. Neurological: Alert and oriented, no focal deficits. Weight: [X] kg, reflecting recent [loss/stability].

Treatment Protocol

Initiate Desmopressin (DDAVP) [nasal spray/oral tablet] at [dose] BID. Monitor serum sodium levels and urine osmolality closely. Maintain strict intake/output (I/O) charting. Ensure free access to water to prevent hypernatremia.

Detailed clinical guide coming soon.