Clinical Presentation & Protocol
Patient Usually Complains Of
Patient presents with a delayed-onset drug reaction characterized by a diffuse maculopapular rash, fever, and systemic involvement. Pulmonary symptoms include dyspnea, non-productive cough, and pleuritic chest pain. Onset follows initiation of [Drug Name] approximately [Number] weeks ago. Associated symptoms include facial edema, lymphadenopathy, and malaise.
Clinical Examination Findings
General: Ill-appearing, febrile. HEENT: Significant facial edema, cervical lymphadenopathy. Skin: Diffuse morbilliform eruption (>50% BSA). Respiratory: Tachypnea, bilateral fine inspiratory crackles on auscultation, decreased breath sounds at bases. Cardiovascular: Tachycardia, regular rhythm. Abdomen: Hepatomegaly noted on palpation.
Treatment Protocol
Immediate discontinuation of the offending agent. Initiate systemic corticosteroids (e.g., Prednisone 1mg/kg/day) with a slow taper. Supportive care includes fluid resuscitation, electrolyte management, and topical emollients for dermatologic symptoms. Monitor pulmonary function tests and chest imaging (HRCT) for interstitial pneumonitis or pleural effusion.