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Gastroenterology & Hepatology

Hepatic Epithelioid Hemangioendothelioma (HEHE)

ICD-10 Code
C22.9

Hepatic Epithelioid Hemangioendothelioma (HEHE) - Clinical guidelines.

Clinical Presentation & Protocol

Patient Usually Complains Of

Patient presents with [asymptomatic incidental finding / RUQ discomfort / constitutional symptoms]. Imaging (CT/MRI) reveals multifocal hepatic nodules with characteristic peripheral enhancement and "lollipop sign" (vessel tethering). No history of chronic liver disease or cirrhosis. Labs show [normal/elevated] LFTs.

Clinical Examination Findings

Abdominal examination: [Soft/distended], [non-tender/tender] to palpation in RUQ. Hepatomegaly noted with [smooth/nodular] edge. No clinical signs of portal hypertension (ascites, splenomegaly, caput medusae). Cardiovascular exam: [Normal/S1S2 regular]. ECOG performance status: [0-4].

Treatment Protocol

Management plan: Multidisciplinary tumor board review. Options discussed: [Observation for stable disease / Surgical resection / Liver transplantation / Systemic therapy (e.g., Sirolimus, Interferon, or Chemotherapy)]. Serial imaging scheduled every [3-6] months to monitor lesion progression.

Detailed clinical guide coming soon.