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Oncology & Cancer Care

Malignant Fibrous Histiocytoma (MFH) of Bone

ICD-10 Code
C41.9

Aggressive primary malignant bone tumor, now formally classified under Undifferentiated Pleomorphic Sarcoma of bone.

Clinical Presentation & Protocol

Patient Usually Complains Of

Patient presents with progressive, deep-seated bone pain, localized swelling, and restricted range of motion in the affected extremity. Symptoms are persistent, non-mechanical, and often nocturnal. No history of recent trauma. Systemic symptoms including unexplained weight loss, fatigue, or low-grade fever noted.

Clinical Examination Findings

Physical examination reveals a palpable, firm, non-tender or mildly tender mass fixed to the underlying bone. Overlying skin may show venous engorgement or erythema. Neurovascular status distal to the lesion is intact. Assessment of regional lymphadenopathy is negative.

Treatment Protocol

Multidisciplinary management initiated. Plan includes core needle biopsy for histopathological confirmation (Undifferentiated Pleomorphic Sarcoma). Staging via MRI of the affected site and CT chest/PET-CT for systemic metastasis. Treatment strategy involves wide surgical resection with negative margins, often combined with neoadjuvant or adjuvant chemotherapy/radiotherapy.

Detailed clinical guide coming soon.