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Oncology & Cancer Care

Multiple Myeloma with Pathological Fracture

ICD-10 Code
C90.00_1

Cancer of plasma cells causing bone lesions and pathological fractures.

Clinical Presentation & Protocol

Patient Usually Complains Of

Patient presents with [site] pain, sudden in onset, following minimal or no trauma. History significant for known Multiple Myeloma, currently [on/off] therapy. Pain is [constant/intermittent], exacerbated by movement, and unresponsive to conservative analgesia. No associated neurological deficits, bowel/bladder incontinence, or constitutional symptoms (fever, night sweats) reported.

Clinical Examination Findings

General: Patient appears [distressed/comfortable], guarding [site]. Musculoskeletal: Localized tenderness, swelling, and crepitus noted at [site]. Range of motion significantly limited due to pain. Neuro: Distal neurovascular status intact; sensation and motor strength [grade] in extremities. No signs of spinal cord compression or radiculopathy.

Treatment Protocol

1. Immobilization of the affected site (brace/splint). 2. Analgesia optimization (multimodal approach). 3. Urgent orthopedic/neurosurgical consultation for stabilization/fixation. 4. Oncology review for systemic therapy adjustment (proteasome inhibitors/IMiDs). 5. Bone-modifying agents (bisphosphonates/denosumab) as indicated. 6. DVT prophylaxis.

Detailed clinical guide coming soon.