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Pulmonology / Respiratory

Pulmonary Veno-Occlusive Disease (PVOD)

ICD-10 Code
I27.89_2

Clinical Criteria for Pulmonary Veno-Occlusive Disease (PVOD).

Clinical Presentation & Protocol

Patient Usually Complains Of

Patient presents with progressive exertional dyspnea, non-productive cough, and fatigue. History notable for worsening functional capacity (WHO FC [I/II/III/IV]). Denies orthopnea or paroxysmal nocturnal dyspnea. No history of connective tissue disease or toxin exposure. Symptoms refractory to standard heart failure management.

Clinical Examination Findings

General: Patient appears tachypneic at rest. HEENT: No jugular venous distension. CV: Loud P2, holosystolic murmur at left sternal border (tricuspid regurgitation). Lungs: Fine bibasilar inspiratory crackles. Extremities: Trace peripheral edema, no clubbing. O2 saturation [X]% on room air.

Treatment Protocol

Caution: Pulmonary vasodilators (e.g., epoprostenol) may precipitate pulmonary edema in PVOD; initiate with extreme caution under specialist supervision. Oxygen therapy for hypoxemia. Diuretics for volume management. Referral for lung transplantation evaluation is mandatory. Avoid systemic anticoagulation unless indicated for other comorbidities.

Detailed clinical guide coming soon.