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Oncology & Cancer Care

Undifferentiated Pleomorphic Sarcoma (UPS), Thigh

ICD-10 Code
C49.21

High-grade soft tissue sarcoma of the thigh, common in older adults (formerly known as MFH).

Clinical Presentation & Protocol

Patient Usually Complains Of

Patient presents with a progressively enlarging, firm, deep-seated mass in the [anterior/posterior/medial/lateral] thigh. Duration of symptoms is [X] months. Patient reports [presence/absence] of localized pain, overlying skin changes, or constitutional symptoms (weight loss, night sweats). No history of prior radiation or trauma to the site.

Clinical Examination Findings

Physical examination reveals a [size in cm] non-tender, firm, fixed mass located in the [specific thigh compartment]. The mass is deep to the fascia, with no evidence of distal neurovascular compromise. Overlying skin is [intact/erythematous/ulcerated]. Regional lymphadenopathy is [absent/present]. Range of motion of the hip and knee is [full/restricted].

Treatment Protocol

Multidisciplinary management plan initiated. Recommended treatment includes wide local excision with negative margins (R0 resection). Preoperative [MRI/CT] imaging reviewed. Consideration for neoadjuvant or adjuvant radiotherapy based on tumor grade and surgical margins. Referral to medical oncology for discussion of systemic chemotherapy if indicated.

Detailed clinical guide coming soon.