Clinical Presentation & Protocol
Patient Usually Complains Of
Patient presents with a clinical picture highly suggestive of Anti-GBM disease, characterized by rapidly progressive glomerulonephritis (RPGN) and/or pulmonary-renal syndrome. Symptoms include acute onset of hematuria, oliguria, and progressive renal failure, accompanied by dyspnea, cough, and hemoptysis. No history of recent infections or nephrotoxic exposure.
Clinical Examination Findings
Patient appears ill, pale, and tachypneic. Vitals reveal hypertension and tachycardia. Skin exam shows no purpura or rashes. Pulmonary exam reveals bilateral crackles or rhonchi. Edema noted in lower extremities.
Treatment Protocol
Immediate initiation of intensive plasma exchange (PLEX) to remove circulating anti-GBM antibodies. Concurrent immunosuppressive therapy with high-dose intravenous methylprednisolone followed by oral prednisone and cyclophosphamide. Monitor renal function and hemoglobin levels closely.