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Nephrology & Renal Medicine

C3 Glomerulonephritis (C3GN)

ICD-10 Code
N04.8_1

C3 glomerulopathy characterized by C3-dominant immunofluorescence (C3 intensity >2 orders of magnitude stronger than any other immune reactant) but lacking the characteristic ribbon-like dense deposits of DDD.

Clinical Presentation & Protocol

Patient Usually Complains Of

Patient presents with [hematuria/proteinuria/nephrotic syndrome]. History significant for [recurrent infections/autoimmune disease]. Current symptoms include [edema/fatigue/foamy urine]. Renal function status: [stable/declining]. No history of dense deposit disease (DDD) features.

Clinical Examination Findings

General appearance: [well-appearing/ill-appearing]. Vital signs: [BP/HR/Temp]. Edema assessment: [pitting edema noted in lower extremities/anasarca]. Skin: [no rashes/purpura]. Weight: [stable/increased].

Treatment Protocol

Initiate [immunosuppressive therapy/complement inhibition (e.g., Eculizumab)]. Blood pressure management: [ACEi/ARB]. Monitor: [C3/C4 levels, urinalysis, serum creatinine]. Dietary: [low sodium/protein-restricted diet].

Detailed clinical guide coming soon.