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Nephrology & Renal Medicine

Citrate Toxicity (During Regional Citrate Anticoagulation)

ICD-10 Code
T50.905A_1

Accumulation of citrate during CRRT when the liver fails to metabolize it (e.g., in severe shock or hepatic failure). Citrate chelates systemic calcium, leading to profound hypocalcemia and metabolic acidosis.

Clinical Presentation & Protocol

Patient Usually Complains Of

Patient currently undergoing CRRT with regional citrate anticoagulation (RCA) presents with clinical signs suggestive of citrate toxicity. Symptoms include circumoral paresthesia, muscle cramps, and altered mental status. Recent labs indicate a widening total-to-ionized calcium ratio (>2.5), metabolic acidosis, and refractory hypocalcemia despite calcium supplementation.

Clinical Examination Findings

Patient appears distressed with positive Chvostek’s and Trousseau’s signs. Neurological assessment reveals hyperreflexia and potential tetany. Hemodynamic status is unstable, potentially secondary to myocardial depression from profound hypocalcemia.

Treatment Protocol

Immediate cessation of citrate infusion. Initiate calcium gluconate or calcium chloride replacement therapy. Increase CRRT blood flow or switch to heparin-based anticoagulation if clinically indicated. Monitor ionized calcium levels every 1-2 hours until stabilization.

Detailed clinical guide coming soon.