Clinical Presentation & Protocol
Patient Usually Complains Of
Patient presents with clinical features of Class IV Lupus Nephritis, including persistent proteinuria, hematuria, and active urinary sediment. Recent labs demonstrate elevated serum creatinine, hypoalbuminemia, and active serologic markers (low C3/C4, elevated anti-dsDNA). Patient reports symptoms of fluid retention, including peripheral edema and hypertension.
Clinical Examination Findings
General appearance: Patient appears chronically ill. Vitals: Hypertension (BP >140/90 mmHg). Skin: Malar rash, alopecia, or vasculitic lesions noted. Extremities: Significant pitting edema (1+ to 3+) noted in lower extremities. Weight: Increased due to fluid retention.
Treatment Protocol
Induction therapy initiated with high-dose corticosteroids and immunosuppressive agents (e.g., Mycophenolate Mofetil or Cyclophosphamide) per protocol. ACE inhibitors/ARBs prescribed for antiproteinuric effect and blood pressure control. Monitor for opportunistic infections and cytopenias.